Key result
Patients with aortic valve sclerosis had higher serum copper levels and lower serum selenium, zinc, and iron concentrations compared with healthy controls (P<0.01).
Why the study?
Aortic valve sclerosis is linked with an imbalance in trace elements, but the relationship with serum iron, zinc, selenium, and copper, as well as their clinical significance as potential biomarkers, required investigation.
Are serum levels of trace elements (Fe, Zn, Se, Cu) altered in patients with aortic valve sclerosis compared to healthy controls?
Case-Control
Are serum levels of trace elements (Fe, Zn, Se, Cu) altered in patients with aortic valve sclerosis compared to healthy controls?
Aortic valve sclerosis is associated with an imbalance in serum trace elements, specifically higher copper and lower selenium, zinc, and iron levels.
Serum trace element monitoring should not yet inform AVSc care; leaves open causal contribution and supplementation potential.
BACKGROUND: Aortic valve sclerosis (AVSc) is defined as the thickening and calcification of aortic valve cusps, in the absence of obstruction of ventricular outflow. AVSc is linked with a clear imbalance in some trace elements. AIMS: The objective of this study was to investigate the relationship between AVSc and serum levels of iron (Fe), zinc (Zn), selenium (Se), and copper (Cu). Additionally, this research aimed to explore the clinical significance of human serum zinc, selenium, copper, and iron concentrations as a potential new biomarker for AVSc patients and to clarify the pathophysiological role in individuals at risk of developing AVSc. PATIENTS AND METHODS: The study included 40 subjects with AVSc (25% male and 75% female) who were compared with a healthy control group with the same gender ratio. AVSc was based on comprehensive echocardiographic assessments. Blood samples were taken and Zn and Cu concentrations were determined through the use of atomic absorption spectroscopy. Se was measured using an inductively coupled plasma mass spectrometry device and Fe was measured using a Beckman Coulter instrument. CONCLUSION: Patients with AVSc had an imbalance in some of the trace elements in their blood. The patient group's valves had higher serum Cu levels and lower serum Se, Zn, and Fe concentrations compared with the healthy group's valves. In the valve patients as compared, AVSc had a high prevalence of obesity, hypertension, and diabetes.
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Al-Taesh et al. (2021) conducted a case-control in Aortic valve sclerosis. Aortic valve sclerosis vs. Healthy control group was evaluated on Serum levels of iron, zinc, selenium, and copper (p=< 0.01). Patients with aortic valve sclerosis had higher serum copper levels and lower serum selenium, zinc, and iron concentrations compared with healthy controls (P<0.01).
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