Key result
Low-dose atorvastatin with crush fluid resuscitation did not significantly differ from other treatments regarding renal function and muscle enzyme levels in a rat crush syndrome model.
Why the study?
Does low-dose atorvastatin combined with crush fluid resuscitation improve renal function and muscle enzyme levels in a rat model of crush syndrome?
RCT
randomly divided
Does low-dose atorvastatin combined with crush fluid resuscitation improve renal function and muscle enzyme levels in a rat model of crush syndrome?
In a rat model of crush syndrome, adding low-dose atorvastatin to crush fluid resuscitation did not provide additional benefit over standard fluid resuscitation strategies for renal and muscle biomarkers.
No renal or muscle benefit from low-dose atorvastatin in rat crush syndrome; leaves open human translation and optimal dosing.
Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250-300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin + crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) + mannitol + sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, and serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels were studied.Results: All parameters were statistically significantly higher in the control group than in the treatment groups at all hours. However, there was no statistically significant difference among treatment groups regarding any of the parameters.Conclusion: This is the first study determining the role of atorvastatin in the treatment of renal ischemia/reperfusion injury in a crush syndrome and rhabdomyolysis model setting. Larger studies with different atorvastatin doses are required to define the role of this drug in the treatment of renal ischemia/reperfusion injury during crush syndrome.
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Acar et al. (2017) conducted an RCT in crush syndrome and rhabdomyolysis. atorvastatin + crush fluid vs. control, crush fluid, and hypertonic saline + mannitol + sodium bicarbonate groups was evaluated on serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels. Low-dose atorvastatin with crush fluid resuscitation did not significantly differ from other treatments regarding renal function and muscle enzyme levels in a rat crush syndrome model.
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