Key result
Antisense 2'-O-allyl oligoribonucleotides efficiently and specifically arrested translation of targeted mRNAs in vitro by blocking cap-dependent translation initiation.
Population
rabbit reticulocyte lysate and wheat germ extract
Design
Preclinical
Authors
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May enable targeted mRNA studies in models; leaves open in vivo validation and clinical translation.
Antisense 2'-O-alkyl oligoribonucleotides provide a novel experimental approach to specifically arrest mRNA translation from defined positions.
Johansson et al. (1994) studied this question. 2'-O-alkyloligoribonucleotides was evaluated on mRNA translation arrest. Antisense 2'-O-allyl oligoribonucleotides efficiently and specifically arrested translation of targeted mRNAs in vitro by blocking cap-dependent translation initiation.
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