Key result
Uric acid concentrations were independently associated with the number and mean area of adipocytes, macrophages number, and adiponectin in apparently healthy subjects.
Why the study?
Studies seek novel biomarkers to identify dysfunctional adipose tissue, and uric acid increases have been suggested to participate in adipose tissue dysfunction.
Are uric acid concentrations associated with morpho-functional adipose tissue markers in apparently healthy subjects?
Observational (n=40)
Are uric acid concentrations associated with morpho-functional adipose tissue markers in apparently healthy subjects?
Uric acid concentrations are independently associated with morpho-functional markers of adipose tissue dysfunction in healthy subjects, suggesting it may be an early instigator of metabolic abnormalities.
Answers are grounded in this paper and cite their sources.
May flag AT dysfunction in healthy adults; leaves open clinical utility pending larger prospective validation.
BACKGROUND: Studies have focused on the search of novel biomarkers that allow to easily identify dysfunctional adipose tissue (AT). Uric acid (UA) could be produced and reabsorbed by AT. It has been suggested that the increases of UA concentrations participates in AT dysfunction. We investigated the association of UA with morpho-functional adipose tissue markers in apparently healthy subjects. METHODS: Forty apparently healthy individuals were included. Dietary habits and anthropometrical features were evaluated. Circulating concentrations of UA, adiponectin, leptin, and plasminogen activator inhibitor-1 (PAI-1) were quantified. Periumbilical subcutaneous AT samples were obtained and adipocyte number, adipocyte area, and macrophages content were assessed. UA showed a significant association with the number and mean area of adipocytes, macrophages number, adiponectin, and PAI-1. Although UA was independently associated with the number and mean area of adipocytes, macrophages number, adiponectin into the adjusted multivariable model. CONCLUSION: UA concentrations are associated with morpho-functional adipose tissue markers. Our results underscore the importance of UA as one earlier instigator of adipose tissue dysfunction in subjects without metabolic abnormalities.
No takes yet. Share an insight, caveat, or question.
Reyes-Barrera et al. (2022) conducted an observational in Apparently healthy (n=40). Uric acid concentrations was evaluated on Morpho-functional adipose tissue markers (adipocyte number, adipocyte area, macrophages content, adiponectin, PAI-1). Uric acid concentrations were independently associated with the number and mean area of adipocytes, macrophages number, and adiponectin in apparently healthy subjects.
Synapse has enriched 10 related papers. Consider them for comparative context: