Key result
Adoptive transfer of a splenic population containing CD8+ T lymphocytes from TMEV-infected resistant donors protected susceptible BALB/c mice against TMEV-induced demyelination.
Adoptive transfer of CD8+ T lymphocytes from resistant mice protects susceptible mice against TMEV-induced demyelinating disease, a model for multiple sclerosis.
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Supports further investigation of CD8+ T cells in demyelination; does not yet inform clinical practice in multiple sclerosis.
Nicholson et al. (1996) studied TMEV-induced demyelinating disease. Adoptive transfer of a splenic population (CD8+ T lymphocytes) from TMEV-infected BALB/cByJ donors was evaluated on Protection against TMEV-induced demyelination. Adoptive transfer of a splenic population containing CD8+ T lymphocytes from TMEV-infected resistant donors protected susceptible BALB/c mice against TMEV-induced demyelination.
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