Key result
Macrophage supernatants significantly enhanced mesangial cell migration at 24 hours (migration score 24.3 vs 11.6, P<0.001) and 48 hours, as well as hillock formation.
Population
In vitro model using cultured mesangial cells (MC)
Comparison
Macrophage supernatants (M phi SN) vs Control
Design
Preclinical
Follow-up
24 and 48 hours
Authors
Loading...
May implicate macrophages in glomerulosclerosis; hypothesis-generating and requires human validation before clinical relevance.
Absolute Event Rate: 24.3% vs 11.6%
p-value: p=<0.001
Macrophage supernatants directly enhance mesangial cell migration and hillock formation, suggesting a mechanism for macrophage involvement in glomerulosclerosis and atherosclerosis.
Mattana et al. (1995) studied Glomerulosclerosis and atherosclerosis (in vitro model). Macrophage supernatants vs. Control was evaluated on Mesangial cell migration score at 24 hours (p=<0.001). Macrophage supernatants significantly enhanced mesangial cell migration at 24 hours (migration score 24.3 vs 11.6, P<0.001) and 48 hours, as well as hillock formation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: