What question did this study set out to answer?

Evaluate the effects of vasoactive agents on monocyte migration across glomerular endothelial cells.

Vasoactive Agents Modulate Migration of Monocytes across Glomerular Endothelial Cells

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In vitro study examines how vasoactive agents impact monocyte migration across endothelial cells, indicating potential therapeutic pathways.

Evaluate the effects of vasoactive agents on monocyte migration across glomerular endothelial cells.
Modified Boyden chamber used to assess monocyte migration across filters and endothelial cells.
Vasoactive agents tested included histamine, PGE2, angiotensin II, endothelin-1, and IL-1.
Microscopic studies (light and scanning electron) conducted to observe changes.
Effects of cAMP on migration also evaluated.
Histamine significantly increased monocyte migration across both the filter and endothelial layer.
PGE2 inhibited monocyte migration in a dose-dependent manner.
Cimetidine reduced histamine's effect on monocyte migration.
Angiotensin II, endothelin-1, and platelet-activating factor had no significant effect on migration.

Singhal et al. (2000) studied this question.

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In vitro study examines how vasoactive agents impact monocyte migration across endothelial cells, indicating potential therapeutic pathways.