Key result
LDV replication involves the formation of a 3'-coterminal-nested set of mRNAs, indicating a genome organization resembling that of coronaviruses and toroviruses.
Population
Primary cultures of mouse macrophages isolated from 10-day-old mice and spleens of 18-h LDV-infected mice
Design
Preclinical
Follow-up
6 to 12 h postinfection; 18-h postinfection
Authors
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Provides a potential model for nidovirus replication; leaves open relevance to human coronavirus pathogenesis.
LDV replication involves the formation of a 3'-coterminal-nested set of mRNAs, indicating a genome organization resembling that of coronaviruses and toroviruses.
Kuo et al. (1991) studied Lactate dehydrogenase-elevating virus (LDV) infection. Lactate dehydrogenase-elevating virus (LDV) infection was evaluated on RNA formation and genome organization. LDV replication involves the formation of a 3'-coterminal-nested set of mRNAs, indicating a genome organization resembling that of coronaviruses and toroviruses.
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