Compounds such as 11β-chloromethyl-17α-[cyclopentadienyl (rhenium tricarbonyl)-ethynyl]-oestradiol are readily accessible, are stable in biological media and show very high affinity for the oestradiol receptor, offering, because of their potential use as radio-pharmaceuticals, new approaches in the treatment of breast cancer.
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Top et al. (1994) studied this question.
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