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When the group A substance decomposing enzyme is allowed to act with group A human saliva, the group A substance is decomposed and at the same time O substance is increased.When the O substance decomposing enzyme is allowed to act with carbohydrate substances from group A human saliva, group A human blood cells and group A hog stomach linings, and after decomposition of O substance, . the A-decomposing enzyme is allowed to act with it, group A specificity disappears and O substance appears. Consequently, it is considered that the A-decomposing enzyme isolates the determinant group of group A substance and transforms it into O substance.
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ISEKI et al. (1953) studied this question.
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