Key result
A physiological atherogenic diet caused severe endothelial dysfunction in rabbits within 4 weeks, decreasing endothelium-dependent relaxation by 63% (P<0.001).
Effect estimate: decreased by 63%
p-value: p=< 0.001
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Rapid diet effects on endothelium warrant short-term rabbit models; leaves open human translation and prevention strategies.
Rai et al. (2009) studied Endothelial dysfunction. Diet supplemented with 1% methionine + 0.1% cholesterol + 5% peanut oil vs. Control diet was evaluated on Endothelium dependent relaxation in response to acetylcholine (decreased by 63%, p=< 0.001). A physiological atherogenic diet caused severe endothelial dysfunction in rabbits within 4 weeks, decreasing endothelium-dependent relaxation by 63% (P<0.001).
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