Key result
The murine coxsackievirus and adenovirus receptor (mCAR) gene is located on the distal portion of murine chromosome 16 and is composed of at least eight exons.
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Genomic mapping of mCAR in mice leaves open its utility for modeling coxsackievirus myocarditis and cardiac gene therapy.
We analyzed BAC genomic clones encoding the murine coxsackievirus and adenovirus receptor (mCAR). The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene. We previously described two cDNAs encoding mCAR isoforms: the extracellular and transmembrane portions of both are encoded by exons 1-6; the cytoplasmic domain of mCAR 1 is encoded by exon 7, whereas mCAR 2 results from an RNA splice linking the proximal portion of exon 7 to an alternative exon 8. RT-PCR analysis of the mCAR RNA 5'-terminus suggests that transcription may begin 141-161 nucleotides upstream of the ATG translational start site.
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Chen et al. (2003) studied this question. The murine coxsackievirus and adenovirus receptor (mCAR) gene is located on the distal portion of murine chromosome 16 and is composed of at least eight exons.
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