Key result
Genetic variants in LPL, FNDC5, and PPARγ genes, including 24 novel variants, were significantly associated with lipid metabolism and body composition parameters in healthy adolescents.
Why the study?
Plasma lipid profile and anthropometric variables are under strong genetic control, making the identification of genetic variants associated with bioclinical parameters of significant public health importance.
Cross-Sectional (n=77)
No
p-value: p=<0.05
Genetic variants in LPL, FNDC5, and PPARγ are significantly associated with lipid metabolism and body composition parameters in healthy adolescents from Southern Italy.
Associations should not change adolescent lipid management; hypothesis-generating for cardiometabolic genetics and needs prospective validation.
BACKGROUND: Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health importance. In this study, a young cohort of healthy individuals was genotyped for genes related to health and pathological conditions, to analyze the association of single nucleotide polymorphisms (SNPs) with different bioclinical parameters, adherence to the Mediterranean Diet (MD) and physical activity, studying the role of lifestyle and body composition parameters on biochemical metabolic profile. METHODS: Association analysis of single variants in the genes of lipoprotein lipase (LPL), fibronectin type III domain containing protein 5 (FNDC5), and peroxisome proliferator-activated receptor-gamma (PPARγ) and haplotype analyses were performed. RESULTS: Multiple (n = 14) common variants in the three genes demonstrated a significant effect on plasma lipoprotein-lipid levels and/or on biochemical parameters in our sample. Specifically, SNPs were related to lipid metabolism (rs3866471, rs4922115, rs11570892, rs248, rs316, rs1059507, rs1801282) or glycemic profile (rs3208305) or anthropometric parameters (rs3480, rs726344, rs1570569) for a total of 26 significant associations (P < 0.01 and/or P < 0.05) and two haplotypes, for the first time, were strongly associated with lipid and body composition parameters. Interestingly, we identified twenty-four new variants not previously described in the literature and a novel significant association between rs80143795 and body composition. CONCLUSIONS: In this study we confirm the association between these SNPs on lipid metabolism and body parameters also in a young cohort, indicating the important role of these genetic factors as determinants of health.
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Perrone et al. (2022) conducted a cross-sectional in Healthy (n=77). LPL, FNDC5, and PPARγ gene polymorphisms vs. Different genotypes / non-carriers was evaluated on Association of single nucleotide polymorphisms with lipid metabolic profile and body composition parameters (p=<0.05). Genetic variants in LPL, FNDC5, and PPARγ genes, including 24 novel variants, were significantly associated with lipid metabolism and body composition parameters in healthy adolescents.
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