Key result
Heterozygous mutation of the SERPINC1 gene (G878A) was present in 5.88% of women with unexplained recurrent pregnancy loss compared to 0% of controls, which was not statistically significant.
Why the study?
A primary etiology cannot be determined in roughly half of recurrent pregnancy loss cases, prompting investigation into whether antithrombin III gene (SERPINC1) mutation is associated with unexplained RPL.
Is antithrombin III gene mutation associated with unexplained recurrent pregnancy loss?
Case-Control (n=68)
No
Is antithrombin III gene mutation associated with unexplained recurrent pregnancy loss?
Absolute Event Rate: 5.88% vs 0%
p-value: p=0.4752
There was no statistically significant association found between the antithrombin III gene (SERPINC1) G878A mutation and unexplained recurrent pregnancy loss in this small cohort.
Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because a primary etiology cannot be determined in roughly half of the instances, it is irritating for both patients and obstetricians. The present study aimed to determine the association of the antithrombin III gene (SERPINC1) mutation with unexplained RPL.Methods: This case-control observational study was conducted at the out-patient department of feto-maternal medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with a total sample size of was 68, with 34 in the control group and 34 in the case/RPL group.Results: The mean±standard deviation (SD) age of the RPL group was 28.44±5.25, and in the control group it was 29.15±4.72. The mean±SD body mass index (BMI) was 24.95±3.48 and 23.69±4.07 in RPL and control groups respectively. Among the RPL group patients, 68% (23) had the primary RPL, and 32% (11) had a second pregnancy loss.Conclusions: 5.88% of the cases have a heterozygous mutation which might be the cause of their RPL. There was no homozygous mutation was found for G878A in the case group. The allele for G878A was also higher in the case group. But these differences were statistically non-significant. So, to clarify this association with unexplained RPL, further research is necessary including multi-centre and large sample sizes.
No takes yet. Share an insight, caveat, or question.
Banu et al. (2022) conducted a case-control in Unexplained recurrent pregnancy loss (n=68). Antithrombin III (SERPINC1) gene mutation vs. No mutation (wild type) was evaluated on Frequency of SERPINC1 G878A heterozygous mutation (p=0.4752). Heterozygous mutation of the SERPINC1 gene (G878A) was present in 5.88% of women with unexplained recurrent pregnancy loss compared to 0% of controls, which was not statistically significant.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: