Key result
Menarchial women had lower resting CK and CK MB activity and responded with a higher efflux of CK and CK MB post-exercise compared to premenarchial and postmenopausal women (p=0.0001).
Why the study?
Does menarchial status and estradiol concentration affect serum CK and CK MB response following exercise-induced muscle damage in females?
Population
40 females of varying menarchial status (15 menarchial, 15 premenarchial, and 10 postmenopausal)
Comparison
Eccentric hamstring contractions vs Comparison across menarchial status groups
Design
Cross-sectional
Authors
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Menarchial status was associated with CK and CK-MB responses to exercise; hypothesis-generating for estradiol effects and requires prospective validation before clinical use.
Observational (n=40)
Does menarchial status and estradiol concentration affect serum CK and CK MB response following exercise-induced muscle damage in females?
p-value: p=0.0001
Estradiol influences resting CK and CK MB activity across menarchial levels but does not significantly reduce their efflux following intense eccentric exercise.
Arnett et al. (2000) conducted an observational in Exercise-induced muscle damage (n=40). Menarchial status vs. Premenarchial and postmenopausal status was evaluated on Serum CK and CK MB activity following exercise-induced muscle damage (p=0.0001). Menarchial women had lower resting CK and CK MB activity and responded with a higher efflux of CK and CK MB post-exercise compared to premenarchial and postmenopausal women (p=0.0001).
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