December 1, 1985Medicine & Science in Sports & Exercise
Creatine kinase isoenzyme activities in men and women following a marathon race
Key result
Men exhibit substantially higher total CK and CK-MB activities than women up to 96 hours post-marathon.
- P<0.05
- n=22
Why the study?
The study aimed to quantify and compare creatine kinase isoenzyme activities and clearance rates in men and women following a marathon race.
Does running a marathon race increase total creatine kinase and CK-MB isoenzyme activities differently in men and women?
Population
14 men and 8 women marathon runners
Comparison
Post-marathon enzyme activities vs pre-marathon baseline
Design
Observational cohort study
Follow-up
96 hours post-race
Authors
Discussion
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Implication
Greater post-marathon CK elevations in men warrant sex-adjusted interpretation; hypothesis-generating for differential muscle damage responses.
Study Design
Type
Observational (n=22)
Structured PICO
Does running a marathon race increase total creatine kinase and CK-MB isoenzyme activities differently in men and women?
P
Population
22 men and women evaluated for serum creatine kinase activity pre- and post-marathon race up to 96 hours.
E
Exposure
Marathon race
C
Comparator
Pre-race baseline (48 h pre-marathon)
O
Outcome
Total serum creatine kinase activity (TCK) and percentage of creatine kinase MB (CK-MB)surrogate
Main Result
Absolute Event Rate: 3322% vs 946%
p-value: p=<0.05
Marathon running causes significant elevations in total CK and CK-MB, with men experiencing substantially higher increases than women.
Cite This Study
Rogers et al. (1985) conducted an observational in Marathon running (n=22). Male sex vs. Female sex was evaluated on Total serum creatine kinase activity (TCK) at 24 hours post-race (p=<0.05). Following a marathon race, men exhibited significantly higher total serum creatine kinase and CK-MB enzyme activities than women at all time points up to 96 hours (P<0.05).