Key result
Heavy-intensity treadmill exercise significantly reduced the average diameter of white adipose cells to 182.44 μm compared to 244.24 μm in sedentary control rats (p<0.001).
Why the study?
Sedentary lifestyle causes lipid accumulation in white adipose cells, and the effect of different exercise intensities on the histological changes of white adipose tissue remained to be determined.
Does treadmill exercise at varying intensities reduce the average diameter of white adipose cells in young rats?
Does treadmill exercise at varying intensities reduce the average diameter of white adipose cells in young rats?
Absolute Event Rate: 182.44% vs 244.24%
p-value: p=<0.001
Moderate and vigorous intensity exercise significantly reduces the size of white adipose cells in a rat model, whereas low-intensity exercise is ineffective.
Moderate-to-vigorous exercise may shrink rat WAT adipocytes; leaves open human relevance and optimal intensity.
Sedentary lifestyle can cause the accumulation of energy reserves in the form of lipids in white adipose cells. Lifestyle modification by means of exercise is done to reduce fat reserves in white adipose tissue (WAT). This study aims to determine the effect of exercise in various intensities on the histological changes of white adipose cells. Research method exploratory with Federer formula to determine the number of samples carried out. Using 28 Wistar rats located at the Central Laboratory of Padjadjran University, Sumedang from May to June 2022. The data taken were the average diameter ± standard error (SEM) of the inguinal white adipose cells of the experimental rats. Data analysis using Microsoft Excel 2016 and SPSS v.28 software. Of the 28 samples studied, only 25 samples met the inclusion criteria. Group K is 0.15% (p = 0.024) greater than P2, and 0.25% (p 0.001) is greater than P3. The P1 group had a value of 0.17% (p = 0.025) greater than P3. Moderate and vigorous exercise can be used to reduce the size of white adipose cells. While low-intensity exercise is considered ineffective. Further research can be carried out to assess changes in white adipose cells based on exercise intensity from other sides besides their morphology.
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Lesmana et al. (2023) studied Sedentary lifestyle (n=28). Treadmill exercise vs. No physical activity (sedentary control) was evaluated on Average diameter of inguinal white adipose cells (p=<0.001). Heavy-intensity treadmill exercise significantly reduced the average diameter of white adipose cells to 182.44 μm compared to 244.24 μm in sedentary control rats (p<0.001).
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