Key result
The presence of two or more risk factors (female sex, hypertension, hyperlipidemia) was associated with an increased risk of incomplete surgical LAA closure (OR 5.1; 95% CI 1.5-17).
Why the study?
In patients with atrial fibrillation, incomplete left atrial appendage closure increases the risk for cardio-embolic events, motivating the need to determine the prevalence and risk factors for incomplete surgical closure in the modern era.
What is the prevalence and what are the risk factors for incomplete surgical closure of the LAA in patients with atrial fibrillation?
Observational (n=74)
What is the prevalence and what are the risk factors for incomplete surgical closure of the LAA in patients with atrial fibrillation?
Odds Ratio: 5.1 (95% CI 1.5–17)
A significant proportion (28%) of surgical LAA closures are incomplete, particularly in patients with multiple risk factors such as female sex, hypertension, and hyperlipidemia.
Persistent incomplete surgical LAA closure may warrant routine post-op TEE surveillance; leaves open optimal technique selection in patients with multiple risk factors.
OBJECTIVES: In patients with atrial fibrillation, incomplete left atrial appendage (LAA) closure is associated with an increased risk for cardio-embolic events compared to complete closure. In this study, we aimed to determine the prevalence and risk factors for incomplete surgical closure of the LAA in the modern surgical era. METHODS: Records of 74 patients with surgical LAA closure who underwent follow-up transesophageal echocardiogram for any reason between 2010 and 2016, were assessed for incomplete closure. Complete closure was defined by absence of Doppler or color flow between the left atrial appendage and the left atrial body in more than 2 orthogonal views. RESULTS: Surgical LAA closure was incomplete in 21 patients (28%) and complete in 53 patients (72%). All included cases were completed via oversewing method with a double layer of running suture with or without excision of the LAA. While no individual demographic, echocardiographic, or surgical feature was significantly different between groups, incomplete closure of the LAA was more prevalent in patients with two or more of the risk factors; female sex, hypertension, and hyperlipidemia (OR 5.1, 95%Cl 1.5-17). CONCLUSIONS: A significant rate of incomplete surgical LAA closure still exists in the modern surgical era, and the presence of multiple risk factors associate an increased risk of incomplete closure.
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A 2020 study conducted an observational in Atrial fibrillation (n=74). Presence of two or more risk factors (female sex, hypertension, hyperlipidemia) vs. Fewer than two risk factors was evaluated on Incomplete surgical closure of the left atrial appendage (OR 5.1, 95% CI 1.5-17). The presence of two or more risk factors (female sex, hypertension, hyperlipidemia) was associated with an increased risk of incomplete surgical LAA closure (OR 5.1; 95% CI 1.5-17).
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