Key result
Intracerebral inoculation of poliomyelitis virus in rhesus monkeys demonstrated that severe lesions in brain centers alone, without spinal cord involvement, can produce acute muscle spasticity.
The study demonstrates that muscle spasticity in acute poliomyelitis can originate from lesions in the brain alone, without spinal cord involvement.
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Challenges spinal-centric model of poliomyelitis spasticity; leaves open human relevance pending clinical studies.
David Bodian (1946) studied Acute poliomyelitis (n=3). Intracerebral inoculation with poliomyelitis virus was evaluated on Presence of lesions or virus in the lumbosacral cord vs brain centers. Intracerebral inoculation of poliomyelitis virus in rhesus monkeys demonstrated that severe lesions in brain centers alone, without spinal cord involvement, can produce acute muscle spasticity.
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