Key result
Acute angulation on lesion ≤90° (HR 2.18) and sequential lesions (HR 1.89) independently predicted clinical failure of rotational atherectomy in patients undergoing complex percutaneous coronary intervention.
Why the study?
Anatomical and procedural predictors of clinical and procedural failure of rotational atherectomy (RA) in an all-comers population needed to be assessed.
Observational (n=534)
Yes
The presence of acute angulation (≤90°) on a lesion and sequential lesions are independent predictors of clinical and procedural failure during rotational atherectomy, emphasizing the need for careful preprocedural anatomical assessment.
Acute angulation ≤90° and sequential lesions predict RA failure; leaves open prospective validation for preprocedural risk scores.
BACKGROUND: The aim of the study was to assess anatomical and procedural predictors of clinical and procedural failure of rotational atherectomy (RA) in an all-comers population. METHODS AND RESULTS: A total of 534 consecutive patients who underwent RA were included in a double-center observational study. The primary composite endpoint consisted of: rota-wire introduction failure, burr-passage failure, periprocedural complications and procedure-related major adverse events. The second primary endpoint included rota-wire introduction failure and burr-passage failure. The primary endpoint occurred in 76 (14.2%) patients and the second primary endpoint occurred in 64 (12%) Periprocedural complications occurred in 23 (4.3%) and procedure-related adverse events in 23 (4.3%) patients. Multivariable analysis revealed angulation on lesion ≤90° (HR=2.18, 95% CI: 1.21-3.94, P=0.0096) and sequential lesion (HR=1.89, 95% CI: 1.01-3.54, P=0.046) as independent predictors of no clinical success of RA. Multivariable analysis revealed again that angulation on lesion ≤90° (HR=2.26, 95% CI: 1.16-4.40, P=0.02) and sequential lesion (HR=3.77, 95% CI: 1.64-8.69, P<0.01) as independent predictors of no procedural success of RA. CONCLUSIONS: The presence of an acute angulation on lesion and sequential lesion are independent determinants of clinical and procedural failure of RA. Further research is necessary to establish a score predicting RA failure, which can help in preproceduralrisk stratification of patients undergoing complex percutaneous coronary intervention with RA.
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Tomasiewicz et al. (2021) conducted an observational in Highly calcified or fibrotic coronary lesions requiring percutaneous coronary intervention with rotational atherectomy (n=534). Acute angulation on lesion (≤90°) vs. Lesions without acute angulation (>90°) was evaluated on Clinical failure of rotational atherectomy (composite of rota-wire introduction failure, burr-passage failure, periprocedural complications, and procedure-related major adverse events within 24 hours) (HR 2.18, 95% CI 1.21-3.94, p=0.0096). Acute angulation on lesion ≤90° (HR 2.18) and sequential lesions (HR 1.89) independently predicted clinical failure of rotational atherectomy in patients undergoing complex percutaneous coronary intervention.
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