November 27, 2017Scientific ReportsOpen Access

Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation

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Population

Anatomically accurate compliant silicone right heart model derived from an in vivo MRI heart scan of a…

Design

Preclinical

Authors

UGUtku GülanStructural Heart Disease ASArdan M. SagunerElectrophysiology DADeniz AkdişElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating for vortex-mediated protection against right atrial thrombus; requires human studies before any clinical consideration.

Structured PICO

Population

Anatomically accurate compliant silicone right heart model derived from an in vivo MRI heart scan of a healthy 25-year-old male.

Intervention

3D Particle Tracking Velocimetry (3D-PTV) under physiological pulsatile flow conditions.

Outcome

Characterization of vortical flow structures and their correlation with wall shear stresses in the right atrium.surrogate

In a healthy right heart model, vortex rings during atrial filling increase wall shear stress, which may provide a rinsing effect that protects against right atrial thrombus formation.

Limitations

Investigated flow patterns in an in vitro physiological right heart model rather than in vivo.
Clinical studies on the differences in the formation of vortical structures in patients with right heart diseases, such as ARVC, are missing.

Cite This Study

Gülan et al. (2017) studied this question.

synapsesocial.com/papers/6a9a87d71c51d4e2d58de04d https://doi.org/10.1038/s41598-017-17117-3

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Implication

Hypothesis-generating for vortex-mediated protection against right atrial thrombus; requires human studies before any clinical consideration.

Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider