Why the study?
Does pretreatment with prostaglandin E1 reduce viral replication in cell cultures?
Does pretreatment with prostaglandin E1 reduce viral replication in cell cultures?
Prostaglandin E1 inhibits viral replication and cell division while enhancing interferon yields in cell cultures.
PGE1 may suppress viral replication and boost interferon in cell culture; hypothesis-generating for antiviral strategies, requiring in vivo validation.
A study has been initiated to determine the influence of prostaglandins on virus replication and its relationship to the interferon system. In the present study, data are presented which show that pretreatment of cells in culture with prostaglandin E1 results in (i) a reduction in the yields of Mengo, MM and polio viruses, (ii) enhanced yields of interferon, and (iii) inhibition of cell division.
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David Giron (1982) studied this question.
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