Key result
Cardiac transplant recipients had an estimated pneumococcal infection incidence of 36 cases per 1000 patient-years, and protective antibody levels significantly decreased post-transplantation (P=0.021).
Why the study?
Are cardiac transplant patients at increased risk of pneumococcal infections and do their protective antibody levels decrease post-transplantation?
Observational (n=129)
Are cardiac transplant patients at increased risk of pneumococcal infections and do their protective antibody levels decrease post-transplantation?
Cardiac transplant recipients have an increased risk of pneumococcal infections and experience a significant decrease in protective pneumococcal antibodies post-transplantation, suggesting a potential benefit for pre-transplant vaccination.
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High pneumococcal infection rates and antibody decline post-transplant in cardiac recipients; leaves open whether vaccination mitigates risk.
Amber et al. (1990) conducted an observational in Cardiac transplant recipients (n=129). Cardiac transplantation was evaluated on Episodes of pneumococcal infection. Cardiac transplant recipients had an estimated pneumococcal infection incidence of 36 cases per 1000 patient-years, and protective antibody levels significantly decreased post-transplantation (P=0.021).
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