Key result
Preloading with crystalloids (67.67% efficacy) showed no statistically significant difference compared to colloids (73.33% efficacy) in preventing hypotension during spinal anesthesia for elective cesarean sections.
Why the study?
The study aimed to compare the efficacy of crystalloids versus colloids as preloading infusions to prevent hypotension, reduce vasopressor requirements, and maintain stable hemodynamics during elective caesarian sections under spinal anesthesia.
Does colloid preloading prevent hypotension better than crystalloid preloading in women undergoing elective C-section under spinal anesthesia?
RCT (n=60)
Double-blind
Closed envelope technique
No
Does colloid preloading prevent hypotension better than crystalloid preloading in women undergoing elective C-section under spinal anesthesia?
Absolute Event Rate: 67.67% vs 73.33%
p-value: p=>0.05
There is no significant difference between crystalloid and colloid preloading in preventing hypotension during spinal anesthesia for elective C-sections.
Equivalent hypotension prevention with crystalloid or colloid preloading; challenges colloid preference and leaves optimal fluid choice open for further RCTs.
Background: Different crystalloids commonly used in preloading are Ringer lactate, normal saline and colloids that are used in preloading are gelatin, dextran, hetastarch, pentastarch, tetrastarch. This study was aimed to compare the efficacy of both as preloading infusion to prevent hypotension, requirement of vasopressors and requirement of total fluid given during surgery to maintain stable hemodynamics Methods: This randomized control trials was conducted in the Department of Anaesthesia , R.V.R.S. Medical College, Bhilwara. 60 patients between 18- 40 years of age, belonging to American society of anaesthesia grade I or II going for elective caesarian section under spinal anesthesia were screened for the study eligibility criteria Results: In group (I), in 20 females, efficacy was achieved while in 10 females efficacy could not be achieved because of drop in BP. In group (II), in 22 females, efficacy was achieved while in 8 females, efficacy could not be achieved. The difference between both groups was statistically insignificant but there were more females in group II in which efficacy was achieved. (p-value=>0.05) Conclusion: According to this randomized trial we did not find any significant difference between both groups for prevention of hypotension.
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Yadav et al. (2019) conducted an RCT in Hypotension during spinal anesthesia for elective cesarean section (n=60). Crystalloid (Ringer lactate) vs. Colloid (gelofusin) 5 ml/kg was evaluated on Efficacy in preventing hypotension (p=>0.05). Preloading with crystalloids (67.67% efficacy) showed no statistically significant difference compared to colloids (73.33% efficacy) in preventing hypotension during spinal anesthesia for elective cesarean sections.
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