Key result
Lower limb amputees had a higher carotid-femoral pulse wave velocity compared to age-matched nonamputees.
Why the study?
Is carotid-femoral pulse wave velocity higher in lower limb amputees compared to age-matched nonamputees?
Cross-Sectional (n=146)
Is carotid-femoral pulse wave velocity higher in lower limb amputees compared to age-matched nonamputees?
Lower limb amputees have higher arterial stiffness as measured by pulse wave velocity compared to nonamputees, suggesting a potential mechanism for increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Supports arterial stiffness assessment in lower limb amputees; hypothesis-generating for causality and longitudinal outcomes.
BACKGROUND: A high carotid-femoral pulse wave velocity (PWV) has been related to increased cardiovascular morbidity and mortality, but has not been previously evaluated in amputees. The aim of this study was to compare PWV between amputees and nonamputees. METHODS: In this cross-sectional study, data were collected from 60 male lower limb amputees and 86 male age-matched nonamputees. PWV was measured noninvasively using a Complior(®) device. All participants underwent laboratory investigations and anthropometry. The difference in PWV between amputee and nonamputees was estimated. Multivariate regression was used to adjust for differences between the groups as a result of potential confounders. RESULTS: PWV was higher in amputees than in nonamputees (10.8 ± 1.9 m/sec versus 9.9 ± 1.8 m/sec, P = 0.008, respectively). This difference remained even after adjusting for confounding factors. CONCLUSION: A higher PWV was demonstrated in lower limb amputees. Routine assessment of PWV may contribute to cardiovascular risk stratification in amputees.
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Magalhães et al. (2011) conducted a cross-sectional in Lower limb amputation (n=146). Lower limb amputation vs. Nonamputees was evaluated on Carotid-femoral pulse wave velocity (PWV) (p=0.008). Lower limb amputees had a higher carotid-femoral pulse wave velocity compared to age-matched nonamputees.
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