Key result
High platelet-derived thrombogenicity during primary percutaneous coronary intervention was associated with a significantly larger enzymatic infarct size (AUC CK 95,231 vs 62,239 IU/L h) in patients with STEMI.
Why the study?
Prompt and potent antiplatelet effects are important in managing STEMI patients undergoing PPCI, motivating evaluation of the association between platelet-derived thrombogenicity during PPCI and enzymatic infarct size.
Is platelet-derived thrombogenicity measured by T-TAS during PPCI associated with enzymatic infarct size in patients with STEMI?
Observational (n=127)
Single-blind
No
Is platelet-derived thrombogenicity measured by T-TAS during PPCI associated with enzymatic infarct size in patients with STEMI?
Absolute Event Rate: 95231% vs 62239%
p-value: p=0.0018
High platelet-derived thrombogenicity measured by T-TAS during primary PCI is associated with larger enzymatic infarct size in STEMI patients.
BACKGROUND: Prompt and potent antiplatelet effects are important aspects of management of ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). We evaluated the association between platelet-derived thrombogenicity during PPCI and enzymatic infarct size in STEMI patients. METHODS AND RESULTS: . CONCLUSIONS: T-TAS-based high platelet-derived thrombogenicity during PPCI was associated with enzymatic infarct size in patients with STEMI.
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Kikuchi et al. (2020) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=127). High platelet-derived thrombogenicity (PL18-AUC10 >110) vs. Low platelet-derived thrombogenicity (PL18-AUC10 ≤110) was evaluated on Area under the curve for creatine kinase (AUC CK) (p=0.0018). High platelet-derived thrombogenicity during primary percutaneous coronary intervention was associated with a significantly larger enzymatic infarct size (AUC CK 95,231 vs 62,239 IU/L h) in patients with STEMI.
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