Key result
Admission MPV > 9.75 predicts large intracoronary thrombus burden during primary PCI for STEMI.
Why the study?
To assess the association of mean platelet volume as a biomarker for angiographic thrombus burden in patients with STEMI undergoing PPCI.
Does mean platelet volume on admission predict angiographic thrombus burden in patients with STEMI undergoing primary PCI?
Observational (n=125)
No
Does mean platelet volume on admission predict angiographic thrombus burden in patients with STEMI undergoing primary PCI?
Higher mean platelet volume on admission is an independent predictor of large angiographic thrombus burden in patients with STEMI undergoing primary PCI.
Answers are grounded in this paper and cite their sources.
MPV may aid thrombus risk stratification in STEMI; hypothesis-generating and requires prospective validation before clinical use.
Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. Objectives: To assess the association of mean platelet volume (MPV) as a biomarker for angiographic thrombus burden in patient with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). Patients and methods: This study was conducted on 125 patients admitted to El-Mokatem health insurance hospital, with the diagnosis of acute ST-segment elevation myocardial infarction (STEMI) treated with PPCI in the period between December 2018 and October 2019. Results: Thrombus burden level determined by TIMI thrombus grade (TIMITG) was significantly higher in the high MPV group (p-value < 0.001). The LTB group had significantly higher admission MPV compared with the STB group (10.42 ± 0.79 vs. 8.88 ±0.84, P < 0.001). In a receiver operating characteristics analysis, MPV > 9.75 predicted LTB with 83.3% sensitivity and 86.2% specificity. Multivariate logistic regression analysis demonstrated MPV was an independent predictor of large intracoronary thrombus burden in patients with STEMI undergoing PPCI Conclusion: In STEMI patients who underwent PPCI, MPV on admission was significantly higher in those who experienced high thrombus burden. MPV on admission may serve as a readily available an independent predictor of the thrombus burden in STEMI patients undergoing PPCI.
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Mehana et al. (2020) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=125). Mean platelet volume (MPV) vs. Low MPV was evaluated on Large intracoronary thrombus burden (LTB) (p=< 0.001). In STEMI patients undergoing primary PCI, an admission mean platelet volume > 9.75 predicted large intracoronary thrombus burden with 83.3% sensitivity and 86.2% specificity.
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