What is the clinical evidence from this study?

Study design: Observational. Population: Acute aortic syndrome (n=19758). Intervention: Time period (2014-2023). Primary outcome: Age- and gender-standardized incidence rate of acute aortic syndrome (Average annual percent change 11.60%).

What does this research mean for the field?

The incidence of hospitalized acute aortic syndrome in Jiangsu Province, China, is 3.30 per 100,000 person-years and is increasing by 11.60% annually, with higher incidence in males and lower mortality in surgically treated patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate province-wide, subtype-specific hospitalized incidence, temporal trends, and postadmission mortality for acute aortic syndrome across Jiangsu Province, China from 2014 to 2023.

September 4, 2026JACC AsiaOpen Access

Acute aortic syndrome incidence rises ~12% annually.

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Why the study?

Population-based evidence on the incidence, temporal trends, and mortality of acute aortic syndrome in China remains limited.

Population

19,758 first-ever hospitalized AAS cases in Jiangsu Province, China

Design

Retrospective, province-wide registry-based study

Key result

The age- and gender-standardized incidence rate of acute aortic syndrome in Jiangsu Province was 3.30 per 100,000 person-years, with an average annual percent change of 11.60%.

Authors

ZXZiwei Xi WYWenda Yu QWQiaochu Wei

Discussion

Member takes

Overview

Rising incidence and surgical survival link in eastern China warrant vigilance; leaves open generalizability and causal factors for sex disparities.

Key Points

To evaluate province-wide, subtype-specific hospitalized incidence, temporal trends, and postadmission mortality for acute aortic syndrome across Jiangsu Province, China from 2014 to 2023.
Conducted a retrospective, province-wide study (N=19,758) using the Jiangsu Medical Record Front Page registry linked to mortality data across 13 cities.
Calculated age- and sex-standardized incidence rates, modeled temporal trends using joinpoint regression, and estimated age effects via age-period-cohort models.
Evaluated postadmission mortality across clinical subtypes and treatment types using weighted landmark Kaplan-Meier analyses.
Identified 19,758 first-ever acute aortic syndrome cases, yielding an age- and gender-standardized incidence rate of 3.30 per 100,000 person-years.
Hospitalized incidence increased significantly over the study period, demonstrating an average annual percent change of 11.60%.
Incidence was markedly higher in male individuals, who developed the condition at younger ages, while surgically treated patients had lower postadmission mortality.

Study Design

Type

Observational (n=19,758)

Multicenter

Yes

Structured PICO

Population

19,758 hospitalized patients with first-ever acute aortic syndrome in Jiangsu Province, China, analyzed from 2014 to 2023.

Outcome

Incidence, temporal trends, and postadmission mortality of hospitalized acute aortic syndromehard clinical

Main Result

Effect estimate: Average annual percent change 11.60%

The incidence of hospitalized acute aortic syndrome in Jiangsu, China is increasing by 11.6% annually, with higher rates and earlier onset in males.

Limitations

The observed increase in hospitalized incidence likely reflected improvements in detection, coding, and subtype classification in addition to changes in disease burden.

Cite This Study

Xi et al. (2026) conducted an observational in Acute aortic syndrome (n=19,758). Time period (2014-2023) was evaluated on Age- and gender-standardized incidence rate of acute aortic syndrome (Average annual percent change 11.60%). The age- and gender-standardized incidence rate of acute aortic syndrome in Jiangsu Province was 3.30 per 100,000 person-years, with an average annual percent change of 11.60%.

synapsesocial.com/papers/6a9ab1705d9e33f25c631f46 https://doi.org/10.1016/j.jacasi.2026.07.021

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September 4, 2026JACC AsiaOpen Access

Acute aortic syndrome incidence rises ~12% annually.

View Full Paper

Ask AI

Bookmark

Why the study?

Population-based evidence on the incidence, temporal trends, and mortality of acute aortic syndrome in China remains limited.

Population

19,758 first-ever hospitalized AAS cases in Jiangsu Province, China

Design

Retrospective, province-wide registry-based study

Key result

The age- and gender-standardized incidence rate of acute aortic syndrome in Jiangsu Province was 3.30 per 100,000 person-years, with an average annual percent change of 11.60%.

Authors

ZXZiwei Xi WYWenda Yu QWQiaochu Wei

Discussion

Member takes

Overview

Rising incidence and surgical survival link in eastern China warrant vigilance; leaves open generalizability and causal factors for sex disparities.

Key Points

To evaluate province-wide, subtype-specific hospitalized incidence, temporal trends, and postadmission mortality for acute aortic syndrome across Jiangsu Province, China from 2014 to 2023.
Conducted a retrospective, province-wide study (N=19,758) using the Jiangsu Medical Record Front Page registry linked to mortality data across 13 cities.
Calculated age- and sex-standardized incidence rates, modeled temporal trends using joinpoint regression, and estimated age effects via age-period-cohort models.
Evaluated postadmission mortality across clinical subtypes and treatment types using weighted landmark Kaplan-Meier analyses.
Identified 19,758 first-ever acute aortic syndrome cases, yielding an age- and gender-standardized incidence rate of 3.30 per 100,000 person-years.
Hospitalized incidence increased significantly over the study period, demonstrating an average annual percent change of 11.60%.
Incidence was markedly higher in male individuals, who developed the condition at younger ages, while surgically treated patients had lower postadmission mortality.

Study Design

Type

Observational (n=19,758)

Multicenter

Yes

Structured PICO

Population

19,758 hospitalized patients with first-ever acute aortic syndrome in Jiangsu Province, China, analyzed from 2014 to 2023.

Outcome

Incidence, temporal trends, and postadmission mortality of hospitalized acute aortic syndromehard clinical

Main Result

Effect estimate: Average annual percent change 11.60%

The incidence of hospitalized acute aortic syndrome in Jiangsu, China is increasing by 11.6% annually, with higher rates and earlier onset in males.

Limitations

The observed increase in hospitalized incidence likely reflected improvements in detection, coding, and subtype classification in addition to changes in disease burden.

Cite This Study

synapsesocial.com/papers/6a9ab1705d9e33f25c631f46 https://doi.org/10.1016/j.jacasi.2026.07.021

Also Consider

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