January 1, 1989Angiology
Indirect, Noninvasive Evaluation of Pressure Wave Transmission in Essential Hypertension
Key result
Sustained essential hypertension was associated with a similar ratio of brachioradial to carotid-femoral pulse wave velocities compared to normotensive subjects, decreasing equally with age.
Why the study?
Does the ratio of brachioradial to carotid-femoral pulse wave velocities differ between patients with essential hypertension and normotensive subjects?
Population
123 male subjects, comprising 32 normal subjects and 91 age-matched patients with sustained essential…
Comparison
Sustained essential hypertension vs Normal (normotensive) subjects
Design
Cross-sectional
Authors
Discussion
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Implication
Similar velocity ratios indicate comparable wave transmission changes with age; leaves open hypertension-specific arterial adaptations beyond aging.
Key Points
- Evaluate arterial pressure wave transmission from the aorta to the brachial artery to determine whether adaptive changes occur in the arterial wall during essential hypertension.
- Assessed 123 male participants, comprising 32 normotensive controls and 91 age-matched patients with sustained essential hypertension.
- Measured blood pressure alongside carotid-femoral (CF) and brachioradial (BR) pulse wave velocities noninvasively, using the BR/CF ratio to assess central-to-peripheral wave transmission.
- The brachioradial to carotid-femoral pulse wave velocity ratio was similar between normotensive and hypertensive subjects and decreased with age to the same extent in both groups.
- In older participants, the age-related reduction in velocity ratio led to nearly identical pulse pressure amplitudes between the aorta and the brachial artery, regardless of hypertensive status.
Study Design
Type
Cross-Sectional (n=123)
Structured PICO
Does the ratio of brachioradial to carotid-femoral pulse wave velocities differ between patients with essential hypertension and normotensive subjects?
P
Population
123 male subjects, comprising 32 normal subjects and 91 age-matched patients with sustained essential hypertension.
E
Exposure
Sustained essential hypertension (observational exposure)
C
Comparator
Normal (normotensive) subjects
O
Outcome
Ratio between brachioradial (BR) and carotid-femoral (CF) pulse wave velocitiessurrogate
Adaptive changes occur in the arterial wall in hypertension, as the effects of age on pressure wave transmission are similar in normal subjects and hypertensive patients.
Cite This Study
Pannier et al. (1989) conducted a cross-sectional in Essential hypertension (n=123). Sustained essential hypertension vs. Normotensive subjects was evaluated on Ratio between brachioradial and carotid-femoral pulse wave velocities. Sustained essential hypertension was associated with a similar ratio of brachioradial to carotid-femoral pulse wave velocities compared to normotensive subjects, decreasing equally with age.