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November 1, 1990Cardiovascular Research

Regional pulse wave velocities in hypertensive and normotensive humans

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Key result

Essential hypertension was associated with higher pulse wave velocity in the iliac artery compared to normotension (780 vs 567 cm/s) and increased wave reflections along the aorta.

Why the study?

Does essential hypertension alter regional pulse wave velocity and wave reflections along the aorta compared to normotensive subjects?

Population

25 subjects with no coronary or valvular heart disease, comprising 17 age-matched subjects with essential…

Comparison

Essential hypertension and sustained isometric… vs Normotensive subjects at baseline.

Design

Cross-sectional

Authors

CTChih-Tai TingMCM. S. ChangSWS P Wang

Discussion

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Overview

Hypothesis-generating for regional aortic stiffness in hypertension; leaves open prognostic value and therapeutic relevance.

Key Points

  • The study aims to compare regional wave transmission and reflection properties in hypertensive and normotensive individuals.
  • Recorded pressure at five aortic regions using micromanometers
  • Baseline comparisons made between normotensive (n=8) and hypertensive (n=17) subjects
  • Analyzed effects of sustained isometric handgrip exercise on pulse wave properties
  • Hypertensives showed higher pulse wave velocity in the iliac artery (780 cm/s vs 567 cm/s in normotensives)
  • Increased wave reflections were present in hypertensives across three regions compared to normotensives
  • Handgrip exercise eliminated differences in pulse wave velocity but not reflection properties

Study Design

Type

Observational (n=25)

Structured PICO

Does essential hypertension alter regional pulse wave velocity and wave reflections along the aorta compared to normotensive subjects?

P
Population
25 subjects (17 hypertensive and 8 age-matched normotensive) without coronary or valvular heart disease.
E
Exposure
Essential hypertension (observational exposure) and sustained isometric handgrip exercise in normotensive subjects.
C
Comparator
Normotensive subjects at baseline.
O
Outcome
Regional pulse wave velocity and wave reflections along the aorta (from ascending aorta to iliac artery).surrogate

Main Result

Absolute Event Rate: 780% vs 567%

Essential hypertension alters regional properties of the aortic wall, increasing peripheral wave-speed and wave reflections, which are not solely dependent on the immediate blood pressure level.

Cite This Study

Ting et al. (1990) conducted an observational in Essential hypertension (n=25). Essential hypertension vs. Normotension was evaluated on Pulse wave velocity in the iliac artery (cm/s). Essential hypertension was associated with higher pulse wave velocity in the iliac artery compared to normotension (780 vs 567 cm/s) and increased wave reflections along the aorta.

synapsesocial.com/papers/6a4af34e321fc44b1362b41fhttps://doi.org/10.1093/cvr/24.11.865
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Indirect, Noninvasive Evaluation of Pressure Wave Transmission in Essential Hypertension1989 · 3 citations
  2. 2Evaluation of segmental elastic properties of the aorta in normotensive and medically treated hypertensive patients by intravascular ultrasound1993 · 28 citations
  3. 3Arterial hemodynamics in human hypertension.1986 · 153 citations
  4. 4Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures.1985 · 457 citations
  5. 5Impact of aortic rather than brachial pulsatile haemodynamics on variations in end-organ measures across the full adult blood pressure range2017 · 5 citations