Key result
Higher body mass index (OR 0.86) and increased tumor apelin expression (OR 0.90) were significantly and independently associated with a lower rate of pathological complete response to neoadjuvant chemotherapy.
Why the study?
Obese individuals have altered response to neoadjuvant chemotherapy, and increased apelin adipokine levels in obesity are associated with poorer cancer prognosis.
Do BMI and tumor apelin expression predict pathological complete response to neoadjuvant chemotherapy in early breast cancer patients?
Observational (n=62)
No
Do BMI and tumor apelin expression predict pathological complete response to neoadjuvant chemotherapy in early breast cancer patients?
Odds Ratio: 0.86 (95% CI 0.74–0.99)
p-value: p=<0.05
Higher BMI and increased tumor apelin expression are independently associated with a lower rate of pathological complete response to neoadjuvant chemotherapy in early breast cancer.
Should not yet guide NAC decisions; hypothesis-generating for apelin as therapeutic target in obese breast cancer.
Obese subjects present higher risk of developing mammary tumors, worse disease free survival and altered response to neoadjuvant chemotherapy (NAC). The circulating levels of the apelin adipokines are increased in obese subjects and are associated with poorer prognosis in cancer patients. In this study, we showed that obesity and tumoral apelin expression are two factors associated with incomplete response to NAC in breast cancer patients.
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Gourgue et al. (2020) conducted an observational in Early breast cancer (n=62). Body mass index (BMI) vs. Lower BMI was evaluated on Pathological complete response (pCR) (OR 0.86, 95% CI 0.74-0.99, p=<0.05). Higher body mass index (OR 0.86) and increased tumor apelin expression (OR 0.90) were significantly and independently associated with a lower rate of pathological complete response to neoadjuvant chemotherapy.
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