July 1, 2001Hypertension
Angiotensinogen Polymorphism M235T, Carotid Atherosclerosis, and Small-Vessel Disease-Related Cerebral Abnormalities
Key result
The angiotensinogen T/T genotype was a significant independent predictor of small-vessel disease-related brain lesion progression (OR 3.19; P=0.002).
Why the study?
Does the angiotensinogen M235T polymorphism predict progression of carotid atherosclerosis and small-vessel disease-related brain abnormalities in community-dwelling subjects without stroke?
Population
431 randomly selected community-dwelling subjects without clinical evidence for strokes
Comparison
Angiotensinogen M235T polymorphism (T/T genotype) vs M/M and M/T genotypes
Design
Cohort, Progression rated by direct imaging comparison by 3 independent raters
Follow-up
3 years
Authors
Discussion
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Implication
T/T genotype associated with SVD progression; hypothesis-generating for genetic risk markers in stroke-free adults, validation needed before clinical use.
Study Design
Type
Cohort (n=431)
Structured PICO
Does the angiotensinogen M235T polymorphism predict progression of carotid atherosclerosis and small-vessel disease-related brain abnormalities in community-dwelling subjects without stroke?
P
Population
431 randomly selected community-dwelling subjects without clinical evidence for strokes, followed for 3 years.
E
Exposure
Angiotensinogen M235T polymorphism (T/T genotype)
C
Comparator
M/M and M/T genotypes
O
Outcome
Progression of carotid atherosclerosis and small-vessel disease-related brain abnormalities (deep or subcortical white matter lesions or lacunes) at 3-year follow-upsurrogate
Main Result
Odds Ratio: 3.19
p-value: p=0.002
The angiotensinogen T/T genotype at position 235 is a genetic marker for the progression of small vessel disease brain lesions, but not for extracranial carotid atherosclerosis.
Cite This Study
Schmidt et al. (2001) conducted a cohort in Carotid atherosclerosis and small-vessel disease-related cerebral abnormalities (n=431). Angiotensinogen T/T genotype vs. M/M and M/T genotypes was evaluated on Progression of small-vessel disease-related brain lesions (OR 3.19, p=0.002). The angiotensinogen T/T genotype was a significant independent predictor of small-vessel disease-related brain lesion progression (OR 3.19; P=0.002).