Key result
Total laryngectomy followed by postoperative radiotherapy successfully treated simultaneous supraglottic leiomyosarcoma and squamous cell carcinoma, with no signs of disease recurrence at 3.5 years.
Why the study?
Leiomyosarcomas rarely occur in the larynx, and evidence regarding the treatment of leiomyosarcoma coexisting with squamous cell carcinoma in the larynx is limited.
Case Report (n=1)
No
This case report highlights the rare presentation and successful management of simultaneous laryngeal leiomyosarcoma and squamous cell carcinoma with laryngectomy and radiotherapy.
Supports laryngectomy plus radiotherapy in rare concurrent laryngeal malignancies; leaves open generalizability without prospective data.
Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx-a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.
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Cooper et al. (2021) conducted a case report in Simultaneous laryngeal leiomyosarcoma and squamous cell carcinoma (n=1). Total laryngectomy and postoperative radiotherapy was evaluated on Disease recurrence. Total laryngectomy followed by postoperative radiotherapy successfully treated simultaneous supraglottic leiomyosarcoma and squamous cell carcinoma, with no signs of disease recurrence at 3.5 years.
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