Key result
In patients with steal-prone coronary anatomy, neither isoflurane nor halothane at 0.5 MAC caused myocardial ischemia by the coronary steal mechanism.
Why the study?
Does isoflurane compared to halothane cause myocardial ischemia via coronary steal in patients with steal-prone coronary anatomy undergoing CABG?
Population
40 patients with steal-prone coronary anatomy undergoing elective coronary artery bypass operations.
Comparison
Isoflurane administered immediately after… vs Halothane administered immediately after…
Design
RCT, randomly assigned
Follow-up
Intraoperative (from preinduction to precannulation)
Authors
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Permits isoflurane or halothane at 0.5 MAC in steal-prone CABG patients; confirms no ischemia via coronary steal in this RCT.
RCT (n=40)
Does isoflurane compared to halothane cause myocardial ischemia via coronary steal in patients with steal-prone coronary anatomy undergoing CABG?
In patients with steal-prone coronary anatomy undergoing CABG, neither isoflurane nor halothane at 0.5 MAC is likely to cause myocardial ischemia via a coronary steal mechanism.
Pulley et al. (1991) conducted an RCT in Steal-prone coronary anatomy (n=40). Isoflurane vs. Halothane was evaluated on Myocardial ischemic episodes (new ECG ST-segment shift ≥0.1 mV, new echocardiographic regional wall motion abnormalities, and/or myocardial lactate production). In patients with steal-prone coronary anatomy, neither isoflurane nor halothane at 0.5 MAC caused myocardial ischemia by the coronary steal mechanism.
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