Key result
Administration of enflurane, halothane, isoflurane, or sufentanil during coronary bypass surgery resulted in similar rates of myocardial ischemia (overall 30.4%, range 27.5%-32.9% across groups).
Why the study?
Does isoflurane anesthesia increase the risk of myocardial ischemia compared to other anesthetics in patients with steal-prone coronary anatomy undergoing CABG?
Population
955 patients who had participated in a randomized trial of the use of one of four primary anesthetics for…
Comparison
Isoflurane anesthesia vs Enflurane, halothane, or sufentanil anesthesia
Design
Cohort, Patients had participated in a randomized trial
Follow-up
During anesthesia
Authors
Loading...
Isoflurane may confer similar ischemia risk during CABG; leaves open randomized confirmation in steal-prone anatomy.
RCT (n=955)
randomized
Does isoflurane anesthesia increase the risk of myocardial ischemia compared to other anesthetics in patients with steal-prone coronary anatomy undergoing CABG?
Isoflurane anesthesia does not increase the frequency of myocardial ischemia in patients with steal-prone coronary anatomy undergoing CABG compared to other primary anesthetics.
Slogoff et al. (1991) conducted an RCT in Coronary artery disease requiring bypass surgery (n=955). Isoflurane, enflurane, halothane, or sufentanil vs. Active comparators (four primary anesthetics) was evaluated on Myocardial ischemia during anesthesia (detected by ≥0.1 mV ST segment displacement). Administration of enflurane, halothane, isoflurane, or sufentanil during coronary bypass surgery resulted in similar rates of myocardial ischemia (overall 30.4%, range 27.5%-32.9% across groups).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: