Key result
Gastrointestinal surgery led to detectable serum CK-MB in 30% and CK-BB in 23% of patients, despite no electrocardiographic evidence of myocardial infarction.
Why the study?
Does gastrointestinal surgery affect serum creatine kinase isoenzyme levels?
Observational (n=30)
Does gastrointestinal surgery affect serum creatine kinase isoenzyme levels?
Gastrointestinal surgery can lead to elevated serum CK-MB and CK-BB isoenzymes without electrocardiographic evidence of myocardial infarction.
Answers are grounded in this paper and cite their sources.
May confound MI diagnosis after GI surgery; leaves open CK isoenzyme specificity versus troponin in postoperative monitoring.
The effect of gastrointestinal surgery on serum creatine kinase activity was studied in 30 patients. The MB isoenzyme was demonstrated in sera of 30% of the patients and BB isoenzyme in 23%. MB content varied from 0.8 to 10.3% of the total creatine kinase activity, and the BB content from 0.6 to 18.4%. The CK-BB was probably of gastrointestinal origin, since gastrointestinal tract contains high CK activity with BB isoenzyme predominating. A cardiac origin for the observed serum CK-MB isoenzyme increase would seem the most likely, although no patients showed evidence of electrocardiographic changes. Increased CK-MB activity has been observed in myocardial ischaemia without infarction.
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Swei H. Tsung (1982) conducted an observational in Gastrointestinal surgery (n=30). Gastrointestinal surgery was evaluated on Presence of MB and BB isoenzymes in serum. Gastrointestinal surgery led to detectable serum CK-MB in 30% and CK-BB in 23% of patients, despite no electrocardiographic evidence of myocardial infarction.
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