Key result
Local hematoma blocks with lidocaine and bupivacaine showed no measurable difference in callus composition, tensile strength, or histological appearance during early fracture repair in rats.
Why the study?
Does injection of local anesthetics (lidocaine and bupivacaine) at the fracture site affect early fracture healing in rats?
Does injection of local anesthetics (lidocaine and bupivacaine) at the fracture site affect early fracture healing in rats?
Local hematoma blocks with lidocaine or bupivacaine do not appear to impair early fracture healing in a rat model.
No impairment in rat fracture healing; leaves open translation to human hematoma block practice.
To test the effects of lidocaine and bupivacaine on early fracture healing, the tensile strength of five groups of femora from normal rats 14 and 35 days after production of a closed diaphyseal fracture were compared. Data indicate that, in experimental animals injected with local anesthetics at the fracture site, no measurable difference is noted in callus composition, tensile strength, or histological appearance during the early phases of fracture repair prior to callus remodeling.
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Henry et al. (2002) studied Closed diaphyseal fracture. Local hematoma blocks (lidocaine and bupivacaine) was evaluated on Callus composition, tensile strength, or histological appearance. Local hematoma blocks with lidocaine and bupivacaine showed no measurable difference in callus composition, tensile strength, or histological appearance during early fracture repair in rats.
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