Key result
Changing the immunosuppressive regimen to cyclosporine and low-dose steroids was associated with reduced frequency and severity of infections following heart transplantation.
Why the study?
Does an immunosuppressive regimen of cyclosporine and low-dose steroids reduce the frequency and severity of infections in heart transplant patients compared to earlier regimens?
Population
64 patients who underwent 66 heart transplants over an 8-year period (1977-1985)
Comparison
Immunosuppressive regimen of cyclosporine and… vs Earlier immunosuppressive regimen
Design
Case_series
Follow-up
up to 8 years (1977-1985)
Authors
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May warrant caution before regimen change; leaves open need for randomized confirmation in heart transplant recipients.
Observational (n=64)
Does an immunosuppressive regimen of cyclosporine and low-dose steroids reduce the frequency and severity of infections in heart transplant patients compared to earlier regimens?
The introduction of cyclosporine and low-dose steroids in heart transplant patients appeared to reduce the frequency and severity of serious infections compared to earlier immunosuppressive regimens.
Reemtsma et al. (1985) conducted an observational in Heart transplant (n=64). Cyclosporine and low-dose steroids vs. Previous immunosuppressive regimen (early series) was evaluated on Frequency and severity of infections. Changing the immunosuppressive regimen to cyclosporine and low-dose steroids was associated with reduced frequency and severity of infections following heart transplantation.
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