Key result
In uniform anisotropic canine ventricular muscle, the decrease in Vmax was proportional to the square of the decrease in conduction velocity with lidocaine, but this relationship was altered with amiodarone.
In canine ventricular muscle, lidocaine alters Vmax and conduction velocity solely via decreased sodium conductance, whereas amiodarone's effects suggest an additional decrease in junctional resistivity.
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Amiodarone alters conduction differently than lidocaine in canine tissue; hypothesis-generating for human mechanisms and should not change practice.
Quinteiro et al. (1990) studied this question. Lidocaine and amiodarone was evaluated on Relationship between Vmax and conduction velocity (θ). In uniform anisotropic canine ventricular muscle, the decrease in Vmax was proportional to the square of the decrease in conduction velocity with lidocaine, but this relationship was altered with amiodarone.
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