Effect of intracoronary saline infusion on dissection during excimer laser coronary angioplasty: A randomized trial
Key result
Intracoronary saline infusion during excimer laser coronary angioplasty reduced the incidence of significant dissection compared with conventional laser irradiation in blood (7% vs 24%; p<0.05).
Why the study?
Does intracoronary saline infusion reduce the incidence of significant coronary artery dissections in patients undergoing excimer laser coronary angioplasty?
Population
Consecutive patients undergoing excimer laser coronary angioplasty
Comparison
Intracoronary saline infusion during excimer… vs Conventional excimer laser coronary angioplasty…
Design
RCT, Randomly assigned, Blinded outcome assessment
Follow-up
Immediate post-procedure
Authors
Discussion
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Implication
Supports saline infusion to lower dissection risk in excimer laser angioplasty; extends RCT evidence for blood-free laser delivery.
Study Design
Type
RCT
Blinding
Single-blind (outcome assessors)
Randomization
Randomly assigned
Structured PICO
Does intracoronary saline infusion reduce the incidence of significant coronary artery dissections in patients undergoing excimer laser coronary angioplasty?
P
Population
Patients undergoing excimer laser coronary angioplasty.
I
Intervention
Intracoronary saline infusion (prewarmed normal saline injected through the coronary artery guide catheter at a rate of 1 to 2 ml/s using a power injector) during excimer laser coronary angioplasty
C
Comparator
Conventional excimer laser coronary angioplasty in a blood medium
O
Outcome
Incidence and severity of coronary artery dissection after excimer laser ablation (significant dissection defined as grade 2 or higher on an ordinal scale of 1 to 5)safety
Main Result
Absolute Event Rate: 7% vs 24%
p-value: p=< 0.05
Intracoronary saline infusion during excimer laser coronary angioplasty significantly reduces the incidence of laser-induced coronary artery dissections compared to conventional laser irradiation in a blood medium.
Cite This Study
Deckelbaum et al. (1995) conducted an RCT in Patients undergoing excimer laser coronary angioplasty. Intracoronary saline infusion vs. Conventional laser irradiation in a blood medium was evaluated on Incidence of significant dissection (grade 2 or higher) (p=< 0.05). Intracoronary saline infusion during excimer laser coronary angioplasty reduced the incidence of significant dissection compared with conventional laser irradiation in blood (7% vs 24%; p<0.05).