Impact of atrial fibrillation on the clinical course of apical hypertrophic cardiomyopathy
Key result
Atrial fibrillation in patients with apical hypertrophic cardiomyopathy was associated with a significantly increased risk of all-cause death (HR 6.58; 95% CI 1.65-26.16; p=0.007) and strokes.
Why the study?
Does atrial fibrillation increase the risk of mortality and stroke in patients with apical hypertrophic cardiomyopathy?
Population
306 consecutive patients with apical hypertrophic cardiomyopathy (ApHCM), mean age 62±11 years, 68% male.
Comparison
Occurrence of atrial fibrillation (AF) vs No atrial fibrillation
Design
Cohort
Follow-up
5.5±2.0 years
Authors
Discussion
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Implication
May warrant closer AF surveillance in apical HCM; leaves open whether intervention improves outcomes.
Study Design
Type
Cohort (n=306)
Structured PICO
Does atrial fibrillation increase the risk of mortality and stroke in patients with apical hypertrophic cardiomyopathy?
P
Population
306 consecutive patients with apical hypertrophic cardiomyopathy (mean age 62 years, 32% female) followed for a mean of 5.5 years.
E
Exposure
Occurrence of atrial fibrillation (AF)
C
Comparator
No atrial fibrillation
O
Outcome
Incidence of all-cause death, cardiovascular death, and strokeshard clinical
Main Result
Hazard Ratio: 6.58 (95% CI 1.65–26.16)
Absolute Event Rate: 11.7% vs 1.3%
p-value: p=0.007
In patients with apical hypertrophic cardiomyopathy, atrial fibrillation is common and associated with a significantly increased risk of stroke and mortality.
Cite This Study
Lee et al. (2017) conducted a cohort in Apical hypertrophic cardiomyopathy (ApHCM) (n=306). Atrial fibrillation vs. No atrial fibrillation was evaluated on All-cause death (HR 6.58, 95% CI 1.65-26.16, p=0.007). Atrial fibrillation in patients with apical hypertrophic cardiomyopathy was associated with a significantly increased risk of all-cause death (HR 6.58; 95% CI 1.65-26.16; p=0.007) and strokes.