Key result
Telmisartan/amlodipine and telmisartan/hydrochlorothiazide similarly reduced systolic (-25.5 vs -24.3 mmHg; P=0.705) and diastolic (-10.8 vs -11.4 mmHg; P=0.832) blood pressure at 12 weeks.
Why the study?
Does telmisartan/amlodipine improve blood pressure reduction compared to telmisartan/hydrochlorothiazide in Japanese patients with uncontrolled hypertension on ARB monotherapy?
Population
75 Japanese hypertensive patients with uncontrolled hypertension despite taking angiotensin II receptor…
Comparison
Fixed-dose combination of telmisartan/amlodipine vs Fixed-dose combination of telmisartan/hydrochloro…
Design
RCT, Assigned randomly
Follow-up
12 weeks
Authors
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Either combination suits Japanese patients uncontrolled on ARB monotherapy; confirms comparable efficacy for flexible dual-therapy selection.
RCT (n=75)
randomly assigned
Does telmisartan/amlodipine improve blood pressure reduction compared to telmisartan/hydrochlorothiazide in Japanese patients with uncontrolled hypertension on ARB monotherapy?
Absolute Event Rate: -25.5% vs -24.3%
p-value: p=0.705
Both telmisartan/amlodipine and telmisartan/hydrochlorothiazide are equally effective in reducing blood pressure in Japanese patients with uncontrolled hypertension on ARB monotherapy, though they have different metabolic profiles.
Kondo et al. (2015) conducted an RCT in Uncontrolled hypertension (n=75). telmisartan/amlodipine vs. telmisartan/hydrochlorothiazide was evaluated on change in office blood pressure from the baseline value at 12 weeks (p=0.705). Telmisartan/amlodipine and telmisartan/hydrochlorothiazide similarly reduced systolic (-25.5 vs -24.3 mmHg; P=0.705) and diastolic (-10.8 vs -11.4 mmHg; P=0.832) blood pressure at 12 weeks.
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