Key result
Coxsackie viruses A-9 and A-10TC reached maximal intracellular titers when only 30% and <10% of cells showed early changes, respectively, indicating cellular changes occurred after virus formation.
Population
Cultures of primary human amnion cells
Comparison
Inoculation with Coxsackie virus strain A-9 and… vs Inoculation with poliovirus strain Mahoney
Design
Preclinical
Follow-up
30 hours
Authors
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These kinetics challenge poliovirus-based models; leaves open virus-specific enteroviral studies in primary cells.
The temporal relationship between virus production and cytopathic changes differs significantly between Coxsackie viruses and poliovirus in primary human amnion cells.
Dunnebacke et al. (1961) studied this question. Coxsackie virus strains A-9 and A-10TC vs. Poliovirus strain Mahoney was evaluated on Intracellular virus titer and cytopathic changes. Coxsackie viruses A-9 and A-10TC reached maximal intracellular titers when only 30% and <10% of cells showed early changes, respectively, indicating cellular changes occurred after virus formation.
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