Population
Suckling mice and primary human amnion cell cultures infected with Coxsackie prototype viruses A-9, A-10…
Comparison
Continuous passages in primary human amnion cell… vs Original animal host (unadapted virus)
Design
Preclinical
Authors
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May inform Coxsackie attenuation strategies; leaves open translation from murine models to clinical use.
Passaging Coxsackie viruses in human amnion cells leads to genetic adaptation that increases in vitro titers and cytopathic effect while attenuating virulence in suckling mice.
Lehmann-Grube et al. (1961) studied this question.
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