Key result
Serial passage of Coxsackie A-9 virus in x-irradiated patas cultures produced a strain with reduced virulence in newborn mice and smaller plaque size, which reverted upon passage in mice or rhesus cultures.
Serial passage of Coxsackie A-9 virus in x-irradiated patas cultures leads to a reversible attenuation of virulence and reduction in plaque size.
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May guide attenuated strain development in cell culture; leaves open applicability to human vaccines or pathogenesis studies.
G. D. Hsiung (1960) studied Coxsackie A-9 virus. Serial passages in x-irradiated patas cultures vs. Original unadapted virus was evaluated on Viral virulence and plaque size. Serial passage of Coxsackie A-9 virus in x-irradiated patas cultures produced a strain with reduced virulence in newborn mice and smaller plaque size, which reverted upon passage in mice or rhesus cultures.
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