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September 4, 2026Journal of the American College of CardiologyOpen Access

Pulmonary Hypertension in Infants, Children, and Young Adults

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Key result

Recent therapeutic advances improve survival and quality of life in young pulmonary hypertension patients.

Why the study?

To provide an update on recent developments in the diagnosis and treatment of children and young adults with pulmonary hypertension, focusing on heterogeneous etiology, pathophysiology, and new therapeutic options.

Design

Review

Authors

GHGeorg Hansmann

Discussion

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Overview

Clinical review demonstrates distinct etiologies and targeted management for pediatric pulmonary hypertension, highlighting the need for age-specific therapeutic strategies.

Key Points

  • To review the epidemiology, etiology, diagnostic evaluation, and therapeutic interventions for pulmonary hypertension across pediatric and young adult populations.
  • Synthesized clinical evidence, hemodynamic guidelines, and classification frameworks across developmental age groups.
  • Evaluated diagnostic pathways involving noninvasive imaging, biomarker monitoring, and comprehensive cardiac catheterization.
  • Assessed medical regimens including targeted pulmonary vasodilators, supportive care, and surgical interventions.
  • Pediatric pulmonary hypertension presents distinct clinical phenotypes heavily driven by congenital heart disease, bronchopulmonary dysplasia, and genetic variants.
  • Targeted pulmonary vasodilators such as prostacyclin pathway agonists, endothelin receptor antagonists, and nitric oxide pathway modulators significantly improve functional class and survival outcomes.

PICO

P
Population
Pulmonary hypertension
I
Intervention / Comparator
PH-targeted therapies and interventional-surgical procedures

Cite This Study

Georg Hansmann (2017) conducted a review in Pulmonary hypertension. PH-targeted therapies and interventional-surgical procedures was evaluated. Recent advancements in pharmacological, surgical, and interventional therapies have contributed to improvements in quality of life and survival for children and young adults with pulmonary hypertension.

synapsesocial.com/papers/6a9b35bccbbdc498ccda9705https://doi.org/10.1016/j.jacc.2017.03.575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pediatric Pulmonary Hypertension2015 · 1,159 citations
  2. 2Survival in Patients with Primary Pulmonary Hypertension1991 · 3,525 citations
  3. 32015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension2015 · 7,042 citations
  4. 4Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension2006 · 626 citations
  5. 5Interdisciplinary Networks for the Treatment of Childhood Pulmonary Vascular Disease: What Pulmonary Hypertension Doctors Can Learn from Pediatric Oncologists2013 · 8 citations