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Chronotherapy, the purposeful alteration of drug levels to match biologic rhythms, has the potential for a therapeutic paradigm shift in the treatment of hypertension.
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Chronotherapeutics, which aligns drug levels with biologic rhythms, represents a potential paradigm shift in the treatment of hypertension to optimize outcomes and minimize side effects.
The treatment of diseases has been based on the concept of homeostasis and has not incorporated an understanding of biologic rhythms and their underlying mechanisms. Biologic rhythms are implicated in cardiovascular events. Failure to recognize the circadian decline in blood pressure may result in iatrogenic chronopathological events, including anterior ischemic optic neuropathy and cerebrovascular accidents. Chronotherapeutics is the purposeful alteration of drug level to match rhythms to optimize therapeutic outcomes and minimize size effects. For the treatment of hypertension, this idea has the potential for a therapeutic paradigm shift.
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L. Michael Prisant (2001) conducted a review in Hypertension. Chronotherapy was evaluated. Chronotherapy, the purposeful alteration of drug levels to match biologic rhythms, has the potential for a therapeutic paradigm shift in the treatment of hypertension.
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