Key result
In hemodialysis patients without prior cardiovascular events, elevated CRP levels were associated with significantly higher left atrial volume index (42 vs 32 mL/m², p=0.015).
Cross-Sectional (n=58)
Absolute Event Rate: 42% vs 32%
p-value: p=0.015
In hemodialysis patients without prior cardiovascular events, elevated CRP levels are associated with left atrial enlargement, suggesting a link between systemic inflammation and left atrial dilation.
Suggests inflammation may drive atrial remodeling in hemodialysis; hypothesis-generating, needs prospective confirmation before clinical relevance.
BACKGROUND: In individuals with concurrent chronic kidney disease (CKD) and cardiovascular disease (CVD), the association between left atrial volume (LAV) and serum levels of C-reactive protein (CRP) is shown. OBJECTIVE: Verify the presence of associations between systemic inflammation and LA dilation in patients on hemodialysis (HD) without clinically evident CVD. METHODS: This was an observational cross-sectional study of a population on HD (> 3 months), which excluded patients with acute or chronic inflammatory diseases (infections, malignancies, autoimmune diseases) hemodynamic instability, use of anti-inflammatory drugs, hyperparathyroidism, arrhythmias, mitral valve disease and prior cardiovascular (CV) events. CRP and interleukin-6 (IL-6) measurements as well as Doppler echocardiography were obtained. Correlation coefficients were determined to evaluate the associations between variables. RESULTS: A total of 58 patients were included (28 men, aged 55 ± 15 years), on HD for 24 ± 16 months, 45% were hypertensive, 26% diabetic, with median CRP of 5.1 mg/dL and IL-6 of 6.1 pg/dL. CRP significantly correlated with LAV (p = 0.040), LAV index (LAVi, p = 0.02) and mitral inflow E wave (p = 0.014). IL-6, despite the strong association with CRP levels (r = 0.75, p < 0.001), did not correlate with echocardiographic indices. Individuals in the top quartile of CRP had significantly higher LAVi than the others (42 ± 17 versus 32 ± 11 mL/m², p = 0.015). CONCLUSIONS: In subjects on HD with no prior CV event, there was an association between elevated CRP levels and LA enlargement. The findings suggest an association between physiopathological processes related to left atrial dilation and systemic inflammatory state of patients on HD.
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Barberato et al. (2013) conducted a cross-sectional in Hemodialysis without clinically evident cardiovascular disease (n=58). Elevated C-reactive protein (CRP) vs. Lower CRP levels was evaluated on Left atrial volume index (LAVi) (p=0.015). In hemodialysis patients without prior cardiovascular events, elevated CRP levels were associated with significantly higher left atrial volume index (42 vs 32 mL/m², p=0.015).
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