Key result
Cardioinhibitory reflex syncope patients had higher resting systolic blood pressure (117.8 vs 109.1 mmHg, p<0.001) and attenuated hemodynamic responses compared to vasodepressor patients.
Why the study?
What are the differences in autonomic balance and hemodynamic responses between cardioinhibitory and vasodepressor types of reflex syncope during orthostatic stress?
Population
74 patients with reflex syncope (36 cardioinhibitory and 38 vasodepressor)
Comparison
Head-up tilt test and active standing test vs Cardioinhibitory vs. vasodepressor patients
Design
Cross-sectional
Authors
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Subtype-specific hemodynamic patterns may aid future phenotyping; cross-sectional data leave causal and therapeutic implications open.
Cross-Sectional (n=74)
What are the differences in autonomic balance and hemodynamic responses between cardioinhibitory and vasodepressor types of reflex syncope during orthostatic stress?
Absolute Event Rate: 117.8% vs 109.1%
p-value: p=< 0.001
Cardioinhibitory reflex syncope is associated with higher resting blood pressure, attenuated hemodynamic responses, and reduced autonomic regulation compared to the vasodepressor type.
Holmegard et al. (2012) conducted a cross-sectional in Reflex syncope (n=74). Cardioinhibitory reflex syncope vs. Vasodepressor reflex syncope was evaluated on Resting systolic blood pressure (p=< 0.001). Cardioinhibitory reflex syncope patients had higher resting systolic blood pressure (117.8 vs 109.1 mmHg, p<0.001) and attenuated hemodynamic responses compared to vasodepressor patients.
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