Key result
Rapid mixing of troponin-C with EDTA or excess TbCl3 yielded Ca2+-release rate constants of 2.8 and 0.7 s-1, respectively, suggesting interactions between the two halves of the molecule.
The study demonstrates interactions between the two halves of the troponin-C molecule, as binding to Ca2+-specific sites enhances affinity for Ca2+-Mg2+ sites.
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Supports allosteric communication in troponin-C; leaves open effects on myofilament function in vivo.
Wang et al. (1983) studied Troponin-C kinetics. Rapid mixing with EDTA or excess TbCl3 was evaluated on Rate constants of Ca2+-release. Rapid mixing of troponin-C with EDTA or excess TbCl3 yielded Ca2+-release rate constants of 2.8 and 0.7 s-1, respectively, suggesting interactions between the two halves of the molecule.
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